RGD-Modified Nanoliposomes Containing Arsenic Trioxide and Erlotinib Induces Cytotoxicity in PC3 Cell Lines
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عنوان دوره: اولین همایش ملی توسعه فناوری نانو در علوم پایه و مهندسی
کد مقاله : 1067-DNBSE
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دانشگاه علوم پزشکی یاسوج
چکیده
During the past few years ago, recent developments in enhancing drug delivery methods improved the treatment of various diseases, particularly in cancer. in this method, the possibility of Controlled Drug Release and Increase bioavailability. Arsenic trioxide and Erlotinib are two drugs approved by the FDA to treat cancer, but their use is limited due to the toxicity of ATO and the low solubility of Erlo. The purpose of this study was to Preparetion RGD-modified NPs to increase the solubility and reduce the toxicity of Erlo and ATO as a new nanosystem for cancer treatment. NPs were prepared by the thin-film hydration method. The effects of the drug and drug-loaded nanoparticles on cell viability was assessed evaluated using (MTT) assay. The Results of MTT showed the IC50 after 48 hours in NPs@ATO-Erlo-RGD showed significant toxicity.
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